- Ularitide is the pharmaceutical version of urodilatin
- Urodilatin is a 32 amino acid hormone of the natriuretic peptide family, secreted from the distale tubulus of the kidney
- Upon binding to the natriuretic peptide receptor A and stimulation of
the particulate guanylate cyclase, ularitide regulates vascular
perfusion, neurohormonal activation and renal function.
- Urodilatin is the kidneys response to decompensating heart failure by accommodating and preserving its renal function
- In acute heart failure, the administration of ularitide is believed to
assure systemic organ perfusion and hence to reduce the short-and long
term clinical complications.
Watch the following mode of action video to find out further information around how ularitide works: